Young Female Patient with Testosterone-Producing Adrenocortical Adenoma Also Showing Signs of Subclinical Cushing's Syndrome

Yoshio Murakami, Kunio Koshimura, Yuzuru Kato, Miharu Sasaki, Nobuyasu Kitamura, Masahiro Tomoi, Hiroshi Yorifuji, Hironobu Sasano, Takashi Suzuki

研究成果: Article査読

4 被引用数 (Scopus)

抄録

A 28-year old female patient with virilization due to left adrenocortical adenoma was studied. The patient had clinical features of hyperandrogenism such as hirsutism and a low pitched voice, but not of hypercorticoidism. Plasma testosterone and dehydroepiandrosterone-sulfate (DHEA-S) were high. Although the basal plasma cortisol concentration and urinary excretion of 17-hydroxycorticosteroids (17-OHCS) were within the normal range, the absence of diurnal variation in plasma cortisol and loss of suppressibility by dexamethasone suggested constitutive secretion of cortisol by the tumor. Inappropriate cortisol secretion was also supported by blunted ACTH response to provocative stimuli. After successful removal of the left adrenal tumor, such endocrinological abnormalities were all normalized. Immunohistochemical analysis revealed that tumor cells were positively stained for C21 hydroxylase cytochrome P-450 (P-450C21) and P-45011β which convert 17-hydroxy (OH) progesterone to cortisol as well as P-450SCC, 3β-hydroxysteroid dehydrogenase and P-45017α which are involved in testosterone biosynthesis. These findings suggest that adrenocortical adenoma secretes predominantly testosterone and constitutively cortisol in a young woman patient with virilization.

本文言語English
ページ(範囲)283-288
ページ数6
ジャーナルendocrine journal
42
2
DOI
出版ステータスPublished - 1995

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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