Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid β proteins in amyloid precursor protein transgenic mice

H. Fujiwara, S. Takayama, K. Iwasaki, M. Tabuchi, T. Yamaguchi, K. Sekiguchi, Y. Ikarashi, Y. Kudo, Y. Kase, H. Arai, N. Yaegashi

研究成果: Article査読

48 被引用数 (Scopus)

抄録

The deposition of amyloid β protein (Aβ) is a consistent pathological hallmark of Alzheimer's disease (AD) brains. Therefore, inhibition of Aβ aggregation in the brain is an attractive therapeutic and preventive strategy in the development of disease-modifying drugs for AD. An in vitro study demonstrated that yokukansan (YKS), a traditional Japanese medicine, inhibited Aβ aggregation in a concentration-dependent manner. An in vivo study demonstrated that YKS and Uncaria hook (UH), a constituent of YKS, prevented the accumulation of cerebral Aβ YKS also improved the memory disturbance and abnormal social interaction such as increased aggressive behavior and decreased social behavior in amyloid precursor protein transgenic mice. These results suggest that YKS is likely to be a potent and novel therapeutic agent to prevent and/or treat AD, and that this may be attributed to UH.

本文言語English
ページ(範囲)305-313
ページ数9
ジャーナルNeuroscience
180
DOI
出版ステータスPublished - 2011 4 28

ASJC Scopus subject areas

  • Neuroscience(all)

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