YKT6 as a second SNARE protein of mammalian autophagosomes

Noboru Mizushima, Takahide Matsui, Hayashi Yamamoto

研究成果: Comment/debate査読

4 被引用数 (Scopus)

抄録

Mammalian autophagosomes possess the Qa-SNARE STX17 (syntaxin 17) for fusion with lysosomes. However, STX17 is not absolutely required for fusion because STX17 knockout cells partially retain autophagosome-lysosome fusion activity. We recently identified YKT6, an R-SNARE, as another autophagosomal SNARE protein that acts independently of STX17 in mammals. Here, we discuss the features and functions of autophagosomal SNARE proteins by comparing STX17 and YKT6. Abbreviations: SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor; STX17, syntaxin 17.

本文言語English
ページ(範囲)176-177
ページ数2
ジャーナルAutophagy
15
1
DOI
出版ステータスPublished - 2019 1 2

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

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