抄録
Mammalian autophagosomes possess the Qa-SNARE STX17 (syntaxin 17) for fusion with lysosomes. However, STX17 is not absolutely required for fusion because STX17 knockout cells partially retain autophagosome-lysosome fusion activity. We recently identified YKT6, an R-SNARE, as another autophagosomal SNARE protein that acts independently of STX17 in mammals. Here, we discuss the features and functions of autophagosomal SNARE proteins by comparing STX17 and YKT6. Abbreviations: SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor; STX17, syntaxin 17.
本文言語 | English |
---|---|
ページ(範囲) | 176-177 |
ページ数 | 2 |
ジャーナル | Autophagy |
巻 | 15 |
号 | 1 |
DOI |
|
出版ステータス | Published - 2019 1 2 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology