WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans

C. E. Rocheleau, J. Yasuda, Ho Shin Tae Ho Shin, R. Lin, H. Sawa, H. Okano, J. R. Priess, R. J. Davis, C. C. Mello

研究成果: Article査読

215 被引用数 (Scopus)

抄録

During C. elegans development, Wnt/WG signaling is required for differences in cell fate between sister cells born from anterior/posterior divisions. A β-catenin-related gene, wrm-1, and the lit-1 gene are effectors of this signaling pathway and appear to downregulate the activity of POP-1, a TCF/LEF-related protein, in posterior daughter cells. We show here that lit- 1 encodes a serine/threonine protein kinase homolog related to the Drosophila tissue polarity protein Nemo. We demonstrate that the WRM-1 protein binds to LIT-1 in vivo and that WRM-1 can activate the LIT-1 protein kinase when coexpressed in vertebrate tissue culture cells. This activation leads to phosphorylation of POP-1 and to apparent changes in its subcellular localization. Our findings provide evidence for novel regulatory avenues for an evolutionarily conserved Wnt/WG signaling pathway.

本文言語English
ページ(範囲)717-726
ページ数10
ジャーナルCell
97
6
DOI
出版ステータスPublished - 1999

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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