Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation

Benjamin Coiffard, Eloi Prud'Homme, Sami Hraiech, Nadim Cassir, Jérôme Le Pavec, Romain Kessler, Federica Meloni, Marc Leone, Pascal Alexandre Thomas, Martine Reynaud-Gaubert, Laurent Papazian, Clemens Aigner, Hakim Ali, Aldo Manuel Álvarez Moran, Todd Astor, John David Aubert, David Bennett, Alessandro Bertani, Alan Betensley, Elodie BlanchardVéronique Boussaud, Marie Budev, Kevin Carney, Daniel Chambers, Kevin Chan, Satish Chandrashekaran, Toyofumi Chen-Yoshikawa, Masayuki Chida, Jose Cifrian, Richard Cornwell, Daniel Dilling, Karen Doucette, Patrick Evrard, Jeremy Falk, Edward Garrity, Reda Girgis, Allan Glanville, Mark Greer, Cynthia Gries, Ramsey Hachem, Amy Hackmann, Chadi Hage, Jan Havlin, Are Martin Holm, Ilhan Inci, Peter Jaksch, Cassie Kennedy, Sarah Kilbourne, Julia Klesney-Tait, Christiane Knoop, Christoph Krapf, Bartosz Kubisa, Johanna M. Kwakkel-van Erp, Tanel Laisaar, Hillevi Larsson, Aurélie Le Borgne, James Lee, Philipp M. Lepper, Robert Levy, Monica Loy, Tanya McWilliams, Takuro Miyazaki, Victor Monforte, Philippe Montravers, Steven Nathan, Andre Nathan Costa, Anna Nolde, Yoshinori Okada, Juan Manuel Ossés, Gian Maria Paganelli, Luca Paoletti, Moo Suk Park, Jas Zarmar, Amit Parulekar, Michael Perch, Charles Poirier, Yoram Puius, Anne Marie Rabain, Reinaldo Rampolla, Robert Reed, Benjamin Renaud-Picard, Gerdt Riise, Ivan Robbins, Lorenzo Rosso, Antoine Roux, Christel Saint-Raymond, Julie Samuel, Marc Schecter, Elena Seminari, Takeshi Shiraishi, Lianne Singer, Jonathan Singer, Astrid Smud, Greg Snell, Paola Soccal, Alessandra Tebaldi, Adrien Tissot, Rade Tomic, Ma Piedad Ussetti, David van Duin, Jose Manuel Vaquero, Federico Venuta, Erik A.M. Verschuuren, Robin Vos, Keith Wille, Ichiro Yoshino, Gordon Yung, Martin Zamora

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Background: Infection is the most common cause of mortality within the first year after lung transplantation (LTx). The management of perioperative antibiotic therapy is a major issue, but little is known about worldwide practices. Methods: We sent by email a survey dealing with 5 daily clinical vignettes concerning perioperative antibiotic therapy to 180 LTx centers around the world. The invitation and a weekly reminder were sent to lung transplant specialists for a single consensus answer per center during a 3-month period. Results: We received a total of 99 responses from 24 countries, mostly from Western Europe (n = 46) and the USA (n = 34). Systematic screening for bronchial recipient colonization before LTx was mostly performed with sputum samples (72%), regardless of the underlying lung disease. In recipients without colonization, antibiotics with activity against gram-negative bacteria resistant strains (piperacillin / tazobactam, cefepime, ceftazidime, carbapenems) were reported in 72% of the centers, and antibiotics with activity against methicillin-resistant Staphylococcus aureus (mainly vancomycin) were reported in 38% of the centers. For these recipients, the duration of antibiotics reported was 7 days (33%) or less (26%) or stopped when cultures of donor and recipients were reported negatives (12%). In recipients with previous colonization, antibiotics were adapted to the susceptibility of the most resistant strain and given for at least 14 days (67%). Conclusion: Practices vary widely around the world, but resistant bacterial strains are mostly targeted even if no colonization occurs. The antibiotic duration reported was longer for colonized recipients.

本文言語English
論文番号109
ジャーナルBMC Pulmonary Medicine
20
1
DOI
出版ステータスPublished - 2020 4 29

ASJC Scopus subject areas

  • 呼吸器内科

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