Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex

Atsushi Kuwahara, Yusuke Hirabayashi, Paul S. Knoepfler, Makoto M. Taketo, Juro Sakai, Tatsuhiko Kodama, Yukiko Gotoh

研究成果: Article査読

65 被引用数 (Scopus)

抄録

Basal progenitors (also called non-surface dividing or intermediate progenitors) have been proposed to regulate the number of neurons during neocortical development through expanding cells committed to a neuronal fate, although the signals that govern this population have remained largely unknown. Here, we show that N-myc mediates the functions of Wnt signaling in promoting neuronal fate commitment and proliferation of neural precursor cells in vitro. Wnt signaling and N-myc also contribute to the production of basal progenitors in vivo. Expression of a stabilized form of β-catenin, a component of the Wnt signaling pathway, or of N-myc increased the numbers of neocortical basal progenitors, whereas conditional deletion of the N-myc gene reduced these and, as a likely consequence, the number of neocortical neurons. These results reveal that Wnt signaling via N-myc is crucial for the control of neuron number in the developing neocortex.

本文言語English
ページ(範囲)1035-1044
ページ数10
ジャーナルDevelopment
137
7
DOI
出版ステータスPublished - 2010 4月 1
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 発生生物学

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