What is the mechanism of the calcium influx to pancreatic acinar cells evoked by secretagogues?

O. H. Petersen, Y. Maruyama

研究成果: Article査読

24 被引用数 (Scopus)

抄録

The simple model shown in Fig. 1 can be used to explain pancreatic acinar stimulus-secretion coupling by assuming that the Ca-activated cation channel is not perfectly selective for mono-valent cations, but enables a very slight leak of divalent cations. Stimulation by ACh or CCK releases intracellular Ca (probably from the plasma membrane) raising [Ca++]i. This opens up the 30-35 pS channels giving rise to Na influx and depolarization. At the same time Ca can leak into the cells through the same channels, maintaining an elevated [Ca++]i. Removal of agonist (and/or inclusion of antagonist) causes a rapid reuptake of Ca into the trigger pool (Stolze and Schulz 1980) causing a decrease in [Ca++]i and closure of the channel with rapid return to the resting potential and the resting [Ca++]i.

本文言語English
ページ(範囲)82-84
ページ数3
ジャーナルPflügers Archiv European Journal of Physiology
396
1
DOI
出版ステータスPublished - 1983 1 1

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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