Washout measurement of radioisotope implanted by radioactive beams in the rabbit

H. Mizuno, T. Tomitani, M. Kanazawa, A. Kitagawa, J. Pawelke, Y. Iseki, E. Urakabe, M. Suda, A. Kawano, R. Iritani, S. Matsushita, T. Inaniwa, T. Nishio, S. Furukawa, K. Ando, Y. K. Nakamura, T. Kanai, K. Ishii

研究成果: Article

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Washout of 10C and 11C implanted by radioactive beams in brain and thigh muscle of rabbits was studied. The biological washout effect in a living body is important in the range verification system or three-dimensional volume imaging in heavy ion therapy. Positron emitter beams were implanted in the rabbit and the annihilation gamma-rays were measured by an in situ positron camera which consisted of a pair of scintillation cameras set on either side of the target. The ROI (region of interest) was set as a two-dimensional position distribution and the time-activity curve of the ROI was measured. Experiments were done under two conditions: live and dead. By comparing the two sets of measurement data, it was deduced that there are at least three components in the washout process. Time-activity curves of both brain and thigh muscle were clearly explained by the three-component model analysis. The three components ratios (and washout half-lives) were 35% (2.0 s), 30% (140 s) and 35% (10 191 s) for brain and 30% (10 s , 19% (195 s) and 52% (3175 s) for thigh muscle. The washout effect must be taken into account for the verification of treatment plans by means of positron camera measurements.

元の言語English
ページ(範囲)2269-2281
ページ数13
ジャーナルPhysics in medicine and biology
48
発行部数15
DOI
出版物ステータスPublished - 2003 8 7

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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    Mizuno, H., Tomitani, T., Kanazawa, M., Kitagawa, A., Pawelke, J., Iseki, Y., Urakabe, E., Suda, M., Kawano, A., Iritani, R., Matsushita, S., Inaniwa, T., Nishio, T., Furukawa, S., Ando, K., Nakamura, Y. K., Kanai, T., & Ishii, K. (2003). Washout measurement of radioisotope implanted by radioactive beams in the rabbit. Physics in medicine and biology, 48(15), 2269-2281. https://doi.org/10.1088/0031-9155/48/15/302