Voltage-sensitive dye versus intrinsic signal optical imaging: Comparison of optically determined functional maps from rat barrel cortex

Ichiro Takashima, Riichi Kajiwara, Toshio Iijima

    研究成果: Article査読

    49 被引用数 (Scopus)

    抄録

    Using intrinsic and voltage-sensitive dye optical imaging methods, somatosensory-evoked neural activity and the consequent metabolic activity were visualized in the barrel cortex at high temporal and spatial resolution. We compared maps of neural and metabolic activity from the perspective of spatial distribution in the cortex. There was good agreement between the two functional maps, if the extent of metabolic activity before a prominent increase in cerebral blood volume (CBV) was assessed. This result indicates that oxygen consumption occurs before CBV changes, in approximately the same cortical area as that in which the preceding neural activity was evoked. This also suggests that the intrinsic signal reflects subthreshold synaptic activity, as well as spiking activity, which is similar to the dye-related signals.

    本文言語English
    ページ(範囲)2889-2894
    ページ数6
    ジャーナルNeuroReport
    12
    13
    DOI
    出版ステータスPublished - 2001 9 17

    ASJC Scopus subject areas

    • 神経科学(全般)

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