Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat

Yusuke Ohsaki, Hitoshi Shirakawa, Kazuyuki Hiwatashi, Yuji Furukawa, Takeo Mizutani, Michio Komai

研究成果: Article

100 引用 (Scopus)

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Vitamin K (K) is essential for blood coagulation and bone metabolism in mammals. K acts as a cofactor in the posttranslational synthesis of γ-carboxyglutamic acid from glutamic acid residues. In addition to the liver and bone, K is found in the brain, heart, kidney and gonadal tissue. However, the physiological role of K in these various organs is not yet fully understood. It is likely that K has functions other than its role as a cofactor of protein γ-glutamyl carboxylation. We used in this study the DNA microarray technique to identify the effect of K status on gene expression in the rat liver. The expression of genes involved in the acute inflammation response was enhanced in rats fed with a K-deficient diet relative to the control and K1-supplemented diet groups. Moreover, dietary supplementation with K1 suppressed the inflammation induced by lipopolysaccharide administration. These results indicate that orally administrated K1 suppressed inflammation in the rat.

元の言語English
ページ(範囲)926-932
ページ数7
ジャーナルBioscience, Biotechnology and Biochemistry
70
発行部数4
DOI
出版物ステータスPublished - 2006 5 5

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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