Visualization of murine lymph vessels using photoacoustic imaging with contrast agents

Ryo Nagaoka, Takuya Tabata, Shin Yoshizawa, Shin ichiro Umemura, Yoshifumi Saijo

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.

本文言語English
ページ(範囲)39-48
ページ数10
ジャーナルPhotoacoustics
9
DOI
出版ステータスPublished - 2018 3

ASJC Scopus subject areas

  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング

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