Vascular Remodeling After Cerebral Ischemia

Y. Nishijima, Y. Akamatsu, K. Masamoto, J. Liu

研究成果: Chapter

抄録

The blood vessels in the adult brain respond to ischemia and hypoxia by remodeling the existing vessels and forming new vessels, a process known as neovascularization. Based on the differences in timing of occurrence and cellular/molecular mechanisms involved, neovascularization can be viewed as three distinct processes, i.e., angiogenesis, vasculogenesis, and arteriogenesis. Despite the differential contribution in neuroprotection and neurorestoration from each, neovascularization is positively correlated with clinical outcome, suggesting that it is a viable target for stroke intervention. In this review we discuss these endogenous revascularization processes, the unique and shared underlying cellular/molecular mechanisms, as well as current known therapies and their limitations in vascular risk factors.

本文言語English
ホスト出版物のタイトルPrimer on Cerebrovascular Diseases
ホスト出版物のサブタイトルSecond Edition
出版社Elsevier Inc.
ページ96-101
ページ数6
ISBN(印刷版)9780128030585
DOI
出版ステータスPublished - 2017 3 7

ASJC Scopus subject areas

  • 神経科学(全般)

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