Variety of laminin exressions in murine neoplastic cell lines: Neuroblastoma NA cells produce only laminin B2 chain

K. Narumi, K. Satoh, M. Isemura, T. Sakai, T. Abe, S. Shindo, Toshiaki Kikuchi, K. Matsushima, M. Motomiya, T. Nukiwa

研究成果: Article査読

2 被引用数 (Scopus)

抄録

In the present study, we investigated the expression of laminin in three murine neoplastic cell lines; 3LL-SA (Lewis lung carcinoma), NA (neuroblastoma) and F9 (teratocarcinoma). Both Western and Northern blot analyses demonstrated that parietal endoderm-like F9 expressed three laminin chains A, B1 and B2. On the other hand, 3LL-SA cells synthesized two laminin chains B1 and B2, and NA cells only B2 chain. The analyses of the restriction fragment length polymorphism indicated that the genes for coding regions of all chains were present and grossly intact both in 3LL-SA and in NA just as in F9. These findings suggest that expression of laminin seems to be transcriptionally regulated in each neoplastic cell line specifically. Since these cell lines produce different forms of laminin, they can be used for investigation of the multifunctions of laminin molecule.

本文言語English
ページ(範囲)133-136
ページ数4
ジャーナルInternational journal of oncology
4
1
出版ステータスPublished - 1994 1 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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