Variants in melanogenesis-related genes associate with skin cancer risk among Japanese populations

Junko Yoshizawa, Yuko Abe, Naoki Oiso, Kazuyoshi Fukai, Yutaka Hozumi, Tomohiro Nakamura, Tomohiko Narita, Tomonori Motokawa, Kazumasa Wakamatsu, Shosuke Ito, Akira Kawada, Gen Tamiya, Tamio Suzuki

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Human skin color is known to be associated with the risk of cutaneous cancer. Some reports indicated that pigmentation-related gene variants were associated with cutaneous cancer risk in Caucasian populations, but there are no similar reports in East Asian populations. This study aimed to evaluate the association between pigmentation-related genes and the risk of skin cancer in Japanese populations. We studied the associations between 12 variants of four pigmentation-related genes and melanin index variations in 198 Japanese patients with skin cancer and compared these findings to those of 500 Japanese controls by using multiple logistic regression analysis. Furthermore, we analyzed an independent sample of 107 Japanese patients with skin cancer. A non-synonymous variant, H615R in the oculocutaneous albinism 2 gene (OCA2), was associated with the risk of malignant melanoma in the Yamagata group (odds ratio [OR], 0.38; 95% confidence interval [CI], 0.17-0.86; P = 0.020). Another non-synonymous variant, A481T in OCA2, was associated with the risk of squamous cell carcinoma and actinic keratosis in the Osaka group (OR, 3.16; 95% CI, 1.41-7.04; P = 0.005). In malignant melanoma cases, the minor allele in OCA2 H615R might have induced the development of lesions in sun-exposed skin (OR, 26.32; 95% CI, 1.96-333; P = 0.014). Our results suggest that some OCA2 variants are definite risk factors for the onset of cutaneous cancer in Japanese populations.

本文言語English
ページ(範囲)296-302
ページ数7
ジャーナルJournal of Dermatology
41
4
DOI
出版ステータスPublished - 2014 4

ASJC Scopus subject areas

  • 皮膚病学

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