Variable gene segment-specific N-insertions at the signal joint of T- cell receptor Vβ-Dβ recombinations

Yasuyoshi Kanari, Ryusuke Nakagawa, Hiroshi Arakawa, Hideo Yamagishi

研究成果: Article査読

6 被引用数 (Scopus)

抄録

The V(D)J recombination of immunoglobulin and a T-cell receptor generates two species of DNA junctions, a coding joint and a signal joint. Non-templated nucleotides (N-nucleotides) are inserted in these DNA junctions. We analyzed the N-insertion at signal joints generated by the Vβ- Dβ recombinations. N-insertions were detected at signal joints of Vβ2, Vβ3, Vβ10, Vβ18 and Vβ14 but not in Vβ8 and Vβ7. These data show that the N-insertion at signal joints is dependent on the Vβ locus used for the recombination. We suggest that the regional chromosomal configuration may differ in recombinase accessibility.

本文言語English
ページ(範囲)151-155
ページ数5
ジャーナルImmunology Letters
61
2-3
DOI
出版ステータスPublished - 1998 4月
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

フィンガープリント

「Variable gene segment-specific N-insertions at the signal joint of T- cell receptor Vβ-Dβ recombinations」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル