Utility of measuring circulating tumor cell counts to assess the efficacy of treatment for carcinomas of unknown primary origin

Keigo Komine, Masahiro Inoue, Kazunori Otsuka, Koji Fukuda, Hiroshi Nanjo, Hiroyuki Shibata

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Background/Aim: Carcinomas of unknown primary origin (CUPs) account for 3%-5% of all malignancies. The majority of CUPs have unfavorable prognosis and are chemoresistant. Predictive biomarkers should be established to improve therapeutic outcomes. Metastatic ability of CUPs may be related to the existence of circulating tumor cells (CTCs). Patients and Methods: Ten patients diagnosed with CUP visiting the Akita University Hospital participated in this study. CTCs were calculated by the CellSearch system. Results: The present observational study indicates that CTCs were detected in 50% of CUPs, and in 80% chemotherapeutically-naïve cases. Furthermore, decrease in CTC count between the pre-treatment and posttreatment phases were observed in chemosensitive cases. Conclusion: Rapid assessment of the efficacy of chemotherapy by CTC count may become a useful predictive biomarker of CUPs.

本文言語English
ページ(範囲)3165-3168
ページ数4
ジャーナルAnticancer research
34
6
出版ステータスPublished - 2014 6月 1
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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