Utility of co-transplanting mesenchymal stem cells in islet transplantation

Naoaki Sakata, Masafumi Goto, Gumpei Yoshimatsu, Shinichi Egawa, Michiaki Unno

研究成果: Review article査読

26 被引用数 (Scopus)

抄録

Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. The mechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.

本文言語English
ページ(範囲)5150-5155
ページ数6
ジャーナルWorld Journal of Gastroenterology
17
47
DOI
出版ステータスPublished - 2011

ASJC Scopus subject areas

  • 消化器病学

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