Utility of B-Mode, Color Doppler and Elastography in the Diagnosis of Breast Cancer: Results of the CD-CONFIRM Multicenter Study of 1351 Breast Solid Masses

Takanori Watanabe, Takuhiro Yamaguchi, Toshitaka Okuno, Sachiyo Konno, Rie Takaki, Megumi Sato, Masahiko Tsuruoka, Hideaki Shirai, Yukari Ogawa, Kanako Ban, Yasuhisa Fujimoto, Koichi Hirokaga, Ryoji Watanabe, Takako Morita

研究成果: Article査読

抄録

The usefulness of color Doppler ultrasound (CD) in distinguishing between benign and malignant breast lesions remains controversial. Our prior study, the Japan Association of Breast and Thyroid Sonology (JABTS) BC-04 study (malignant: 839, benign: 569), found CD was useful in breast cancer diagnosis, and we developed CD diagnostic criteria. The first aim of the current study (the CD-CONFIRM study) was to evaluate the usefulness of the CD diagnostic criteria. The second aim was to evaluate the relationship between CD and elastography. We evaluated ultrasound images of breast masses from 13 institutions (malignant: 639, benign: 712). While the sensitivity of B-mode alone was very high and was not significantly improved with CD, the specificity was significantly improved with CD (61.2%–69.2%, p < 0.0001). Furthermore, the specificity of the combination of B-mode and CD improved significantly with the addition of elastography (72.8%–79.0%, p < 0.0001). This study found that the CD criteria are useful, and CD and elastography are independent.

本文言語English
ページ(範囲)3111-3121
ページ数11
ジャーナルUltrasound in Medicine and Biology
47
11
DOI
出版ステータスPublished - 2021 11

ASJC Scopus subject areas

  • 放射線技術および超音波技術
  • 生物理学
  • 音響学および超音波学

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