TY - JOUR
T1 - Utility of B-Mode, Color Doppler and Elastography in the Diagnosis of Breast Cancer
T2 - Results of the CD-CONFIRM Multicenter Study of 1351 Breast Solid Masses
AU - Watanabe, Takanori
AU - Yamaguchi, Takuhiro
AU - Okuno, Toshitaka
AU - Konno, Sachiyo
AU - Takaki, Rie
AU - Sato, Megumi
AU - Tsuruoka, Masahiko
AU - Shirai, Hideaki
AU - Ogawa, Yukari
AU - Ban, Kanako
AU - Fujimoto, Yasuhisa
AU - Hirokaga, Koichi
AU - Watanabe, Ryoji
AU - Morita, Takako
N1 - Funding Information:
The authors have no conflicts of interest to declare. This research was supported by the Research and Development Committee Program of the Japan Society of Ultrasonics in Medicine and the Japan Association of Breast and Thyroid Sonology.
Publisher Copyright:
© 2021 The Authors
PY - 2021/11
Y1 - 2021/11
N2 - The usefulness of color Doppler ultrasound (CD) in distinguishing between benign and malignant breast lesions remains controversial. Our prior study, the Japan Association of Breast and Thyroid Sonology (JABTS) BC-04 study (malignant: 839, benign: 569), found CD was useful in breast cancer diagnosis, and we developed CD diagnostic criteria. The first aim of the current study (the CD-CONFIRM study) was to evaluate the usefulness of the CD diagnostic criteria. The second aim was to evaluate the relationship between CD and elastography. We evaluated ultrasound images of breast masses from 13 institutions (malignant: 639, benign: 712). While the sensitivity of B-mode alone was very high and was not significantly improved with CD, the specificity was significantly improved with CD (61.2%–69.2%, p < 0.0001). Furthermore, the specificity of the combination of B-mode and CD improved significantly with the addition of elastography (72.8%–79.0%, p < 0.0001). This study found that the CD criteria are useful, and CD and elastography are independent.
AB - The usefulness of color Doppler ultrasound (CD) in distinguishing between benign and malignant breast lesions remains controversial. Our prior study, the Japan Association of Breast and Thyroid Sonology (JABTS) BC-04 study (malignant: 839, benign: 569), found CD was useful in breast cancer diagnosis, and we developed CD diagnostic criteria. The first aim of the current study (the CD-CONFIRM study) was to evaluate the usefulness of the CD diagnostic criteria. The second aim was to evaluate the relationship between CD and elastography. We evaluated ultrasound images of breast masses from 13 institutions (malignant: 639, benign: 712). While the sensitivity of B-mode alone was very high and was not significantly improved with CD, the specificity was significantly improved with CD (61.2%–69.2%, p < 0.0001). Furthermore, the specificity of the combination of B-mode and CD improved significantly with the addition of elastography (72.8%–79.0%, p < 0.0001). This study found that the CD criteria are useful, and CD and elastography are independent.
KW - Breast cancer
KW - Color Doppler
KW - Diagnostic criteria
KW - Elastography
KW - Multicenter study
KW - Ultrasound
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U2 - 10.1016/j.ultrasmedbio.2021.07.009
DO - 10.1016/j.ultrasmedbio.2021.07.009
M3 - Article
C2 - 34456085
AN - SCOPUS:85114710402
VL - 47
SP - 3111
EP - 3121
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
SN - 0301-5629
IS - 11
ER -