Usefulness of targeting lymphocyte Kv1.3-channels in the treatment of respiratory diseases

Itsuro Kazama, Tsutomu Tamada, Masahiro Tachi

研究成果: Review article査読

12 被引用数 (Scopus)

抄録

T lymphocytes predominantly express delayed rectifier K+-channels (Kv1.3) in their plasma membranes. Patch-clamp studies revealed that the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo studies further revealed the clinically relevant relationship between the channel expression and the development of chronic respiratory diseases, in which chronic inflammation or the overstimulation of cellular immunity in the airways is responsible for the pathogenesis. In chronic respiratory diseases, such as chronic obstructive pulmonary disease, asthma, diffuse panbronchiolitis and cystic fibrosis, in addition to the supportive management for the symptoms, the anti-inflammatory effects of macrolide antibiotics were shown to be effective against the over-activation or proliferation of T lymphocytes. Recently, we provided physiological and pharmacological evidence that macrolide antibiotics, together with calcium channel blockers, HMG-CoA reductase inhibitors, and nonsteroidal anti-inflammatory drugs, effectively suppress the Kv1.3-channel currents in lymphocytes, and thus exert anti-inflammatory or immunomodulatory effects. In this review article, based on the findings obtained from recent in vivo and in vitro studies, we address the novel therapeutic implications of targeting the lymphocyte Kv1.3-channels for the treatment of chronic or acute respiratory diseases.

本文言語English
ページ(範囲)753-765
ページ数13
ジャーナルInflammation Research
64
10
DOI
出版ステータスPublished - 2015 10 13

ASJC Scopus subject areas

  • 免疫学
  • 薬理学

フィンガープリント

「Usefulness of targeting lymphocyte Kv1.3-channels in the treatment of respiratory diseases」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル