Usefulness of LigaSure for liver resection: analysis by randomized clinical trial

Akio Saiura, Junji Yamamoto, Rintaro Koga, Yoshihiro Sakamoto, Norihiro Kokudo, Makoto Seki, Takuhiro Yamaguchi, Toshiharu Yamaguchi, Tetsuichiro Muto, Masatoshi Makuuchi

研究成果: Article査読

117 被引用数 (Scopus)

抄録

Background: The goal of the present study was to evaluate the efficacy of the novel LigaSure Vessel Sealing System (Valleylab, Boulder, CO) when used for liver resection. Methods: Sixty patients (n = 30 in each group) with liver pathology from a single center were randomized to undergo liver resection with either the LigaSure system or with conventional clamping methods. Patients were stratified according to tumor size (<5 or >5 cm), type of hepatectomy (minor or major), and liver damage (normal or injured). Estimated blood loss during liver transection was used as the primary end point, whereas liver transection speed and morbidity rate were used as secondary end points. Results: There were no hospital deaths. The median blood loss during liver transection was less in the LigaSure than in the conventional group (200 vs 322 mL; P = .185). The amount of blood loss during minor hepatectomy was significantly less in the LigaSure than in the conventional group (186 vs 412 mL, P = .012). The liver transection speed was significantly faster in the LigaSure than in the conventional group (2.3 vs 1.6 cm2/min, P < .001. The number of ties required during liver transection was significantly less in the LigaSure than in the conventional group (6 vs 69 ties, P < .001). The morbidity rate was similar when comparing the 2 groups, indicating that the LigaSure sealing device and conventional methods had comparable efficacy in sealing the bile duct in the portal triad. Postoperative bile leak was observed in 1 patient (3%) in the LigaSure group and in 3 patients (9%) in the conventional group (P = .301). Conclusions: The LigaSure system is an effective and safe tool for decreasing liver resection time.

本文言語English
ページ(範囲)41-45
ページ数5
ジャーナルAmerican Journal of Surgery
192
1
DOI
出版ステータスPublished - 2006 7
外部発表はい

ASJC Scopus subject areas

  • Surgery

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