Usefulness of cell block cytology for preoperative grading and typing of intraductal papillary mucinous neoplasms

M. Monzen, K. Shimizu, T. Hatori, Toru Furukawa, K. Shiratori

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Background: Precise histological diagnosis is important for the successful management of intraductal papillary mucinous neoplasms (IPMNs). Object: The object of this study was to determine whether cell block cytology is useful for preoperative cytomorphological grading and typing of IPMNs. Methods: The subjects were 23 patients with IPMN from whom pancreatic juice was collected via a pancreatic catheter and who subsequently underwent pancreatic resection. Results: In 20 of the 23 cases, the quantity of cells collected for cell block cytology was sufficient to enable typing and grading of the IPMN. The rates of consistency between the results of typing and grading by cell block cytology and histological examination of the surgical specimen were 95% and 80%, respectively. Typing of the 10 main-duct/mixed-duct-type IPMNs by cell block cytology yielded 5 gastric types, 3 intestinal types, 1 oncocytic type, and 1 pancreatobiliary type, and the typing was consistent with the surgical diagnosis in all 10 cases. The results of typing of the branch-duct-type IPMNs by cell block cytology were identical to the results of histological typing in the surgical specimens in every case but one. However, the specificity of cell block cytology for grading IPMNs was 55.6%. Conclusions: The cell block cytological findings were fairly consistent with the histopathological features of the surgical specimens, thereby indicating that cell block cytology may be useful for preoperative and typing of IPMNs, but only play a supplementary role in grading IPMNs.

本文言語English
ページ(範囲)369-378
ページ数10
ジャーナルPancreatology
13
4
DOI
出版ステータスPublished - 2013 1月 1
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 肝臓学
  • 内分泌学

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