Use of polystyrene-supported DBU in the synthesis and α-selective glycosylation study of the unstable schmidt donor of L-kedarosamine

Isao Ohashi, Martin James Lear, Fumihiko Yoshimura, Masahiro Hirama

研究成果: Article査読

18 被引用数 (Scopus)

抄録

In the α-glycosylation study of the unusual, 2-deoxy amino sugar of kedarcidin, polystyrene-supported DBU (PDBU) was found to be invaluable to the clean preparation of the highly labile Schmidt donor of L-kedarosamine. By further recognition that the C4-alcohol should be left free for favorable acceptor reactivity, we could for the first time successfully assemble the C13-O-α-glycoside of the ansamacrolide substructure of the kedarcidin chromophore.

本文言語English
ページ(範囲)719-722
ページ数4
ジャーナルOrganic letters
6
5
DOI
出版ステータスPublished - 2004 3 4

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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