Use of abasic site-containing DNA for electrochemical SNPs detection.

Kotaro Morita, Seiichi Nishizawa, Norio Teramae

研究成果: Article査読

1 被引用数 (Scopus)

抄録

In combination with an electrode modified with an abasic site-containing DNA duplex, flavins selectively bind to thymine with a useful electrochemical response, and flavins could be successfully utilized for detection of thymine-related mutations. The abasic site provides hydrophobic microenvironments for the hydrogen bond-forming ligands can recognize the specific target base in the DNA duplex, which is detected by the difference in the electrochemical response.

本文言語English
ページ(範囲)91-92
ページ数2
ジャーナルNucleic acids symposium series (2004)
50
DOI
出版ステータスPublished - 2006

ASJC Scopus subject areas

  • 医学(全般)

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