Use of a clinical MRI scanner for preclinical research on rats

Akihide Yamamoto, Hiroshi Sato, Jun Ichiro Enmi, Kenji Ishida, Takayuki Ose, Atsuomi Kimura, Hideaki Fujiwara, Hiroshi Watabe, Takuya Hayashi, Hidehiro Iida

研究成果: Article査読

8 被引用数 (Scopus)

抄録

This study evaluated the feasibility of imaging rat brains using a human whole-body 3-T magnetic resonance imaging (MRI) scanner with specially developed transmit-and-receive radiofrequency coils. The T1- and T 2-weighted images obtained showed reasonable contrast. Acquired contrast-free time-of-flight magnetic resonance angiography images clearly showed the cortical middle cerebral artery (MCA) branches, and interhemispheric differences could be observed. Dynamic susceptibility contrast MRI at 1.17 mm3 voxel resolution, performed three times following administration of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA, 0.1 mmol/kg), demonstrated that the arterial input function (AIF) can be obtained from the MCA region, yielding cerebral blood flow (CBF), cerebral blood volume, and mean transit time (MTT) maps. The hypothalamus (HT) to parietal cortex (Pt) CBF ratio was 45.11 ± 2.85%, and the MTT was 1.29 ± 0.40 s in the Pt region and 2.32 ± 0.17 s in the HT region. A single dose of Gd-DTPA enabled the assessment of AIF within MCA territory and of quantitative CBF in rats.

本文言語English
ページ(範囲)13-21
ページ数9
ジャーナルRadiological Physics and Technology
2
1
DOI
出版ステータスPublished - 2009 1
外部発表はい

ASJC Scopus subject areas

  • 放射線
  • 理学療法、スポーツ療法とリハビリテーション
  • 放射線学、核医学およびイメージング

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