Up-regulation of α4 integrin on activated langerhans cells: Analysis of adhesion molecules on langerhans cells relating to their migration from skin to draining lymph nodes

Setsuya Aiba, Satoshi Nakagawa, Hiroaki Ozawa, Kensuke Miyake, Hideo Yagita, Hachiro Tagami

研究成果: Article査読

60 被引用数 (Scopus)

抄録

After hapten application, epidermal Langerhans cells migrate into the regional lymph nodes through dermal lymphatics. Recently, we have demonstrated that some of them take the phenotypic and functional characteristics similar to those of in vitro cultured Langerhans cells, before disappearing from the epidermis. To analyze the mechanisms underlying the migration of Langerhans cells, we studied the expression of several adhesion molecules on freshly isolated LC and cultured LC. Pgp-1 (CD44), intercellular adhesion molecule 1, and α4 integrin were strongly expressed on cultured Langerhans cells. Among them, only α4 integrin was strongly up-regulated by cultured Langerhans cells, because its expression by freshly isolated Langerhans cells was very weak. This up-regulation of α4 integrin was also observed on in vivo activated Langerhans cells in the epidermis and draining lymph nodes after hapten application. These data suggest a possible role played by VLA-4 in the migration of Langerans cells from the epidermis into the regional lymph nodes after hapten application.

本文言語English
ページ(範囲)143-147
ページ数5
ジャーナルJournal of Investigative Dermatology
100
2
DOI
出版ステータスPublished - 1993 2月
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 皮膚病学
  • 細胞生物学

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