Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi

Ying Ye, Atsushi Minami, Yuya Igarashi, Miho Izumikawa, Myco Umemura, Nozomi Nagano, Masayuki Machida, Teppei Kawahara, Kazuo Shin-ya, Katsuya Gomi, Hideaki Oikawa

研究成果: Article査読

46 被引用数 (Scopus)

抄録

The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results confirmed an essential requirement for novel oxidases possessing the DUF3328 motif for macrocyclization, and highly unique side-chain modifications by three oxidases (UstCF1F2) and a pyridoxal 5′-phosphate (PLP)-dependent enzyme (UstD). These findings provide new insight into the expression of the RiPP gene clusters found in various fungi.

本文言語English
ページ(範囲)8072-8075
ページ数4
ジャーナルAngewandte Chemie - International Edition
55
28
DOI
出版ステータスPublished - 2016 7 4

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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