Unexpected chiroptical inversion observed for supramolecular complexes formed between an achiral polythiophene and ATP

Chun Li, Munenori Numata, Masayuki Takeuchi, Seiji Shinkai

研究成果: Article査読

47 被引用数 (Scopus)

抄録

A series of supramolecular complexes between a water-soluble achiral polythiophene derivative (PT-1) and various nucleotides has been prepared. It was found that upon the introduction of adenosine diphosphate (ADP), adenosine triphosphate (ATP), and uridine triphosphate (UTP) into aqueous solutions of achiral PT-1, which has a random-coiled conformation, chiral supramolecular π-stacked aggregates of PT-1 can be constructed. These complexes exhibit an unique split-type induced circular dichroism (ICD) in the π-π* transition region of the main chain. In particular, it was found that the Cotton effect of the chiral supramolecular PT-1/ATP aggregates reveals a dramatic inversion of chirality with a change in the concentration of ATP, which has not been previously observed in chiral macromolecular complexes. On the basis of extensive investigations performed with UV/ Vis spectroscopy, CD spectroscopy, TEM, AFM, and dynamic light scattering (DLS), a possible mechanism for the formation of chiral superstructures of PT-1 and chiroptical inversion induced by changes in ATP concentration is proposed.

本文言語English
ページ(範囲)95-101
ページ数7
ジャーナルChemistry - An Asian Journal
1
1-2
DOI
出版ステータスPublished - 2006
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 有機化学

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