This paper reports a preliminarily experimental result of high-speed shadowgraph optical visualization of underwater expansion wave focusing by using a simple two-dimensional wedge model for understanding of shock wave interaction phenomena in simulated biomedical materials. Underwater shock wave generated by detonating a micro-explosive (10 mg silver azide pellet) in a small chamber. The generated underwater shock wave was interacted with a wedge shaped interface between water and air divided by a thin film, and an expansion wave was generated by reflection at the interface. The process of underwater expansion wave generation and focusing phenomena was visualized by shadowgraph method and recorded by ultra-high-speed framing camera. Underwater shock wave was reflected as an expansion wave from the interface between water and air at the both side and focused and then cavitation bubble was created by pressure decreasing at the expansion wave focusing area. The pressure histories were measured simultaneously with high-speed optical visualization by a needle type pressure sensor. At the focusing area, the pressure was decreased rapidly, the negative peak pressure was the lowest.