Ubiquitination-mediated autophagy against invading bacteria

Naonobu Fujita, Tamotsu Yoshimori

    研究成果: Review article査読

    37 被引用数 (Scopus)

    抄録

    Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.

    本文言語English
    ページ(範囲)492-497
    ページ数6
    ジャーナルCurrent Opinion in Cell Biology
    23
    4
    DOI
    出版ステータスPublished - 2011 8

    ASJC Scopus subject areas

    • Cell Biology

    フィンガープリント 「Ubiquitination-mediated autophagy against invading bacteria」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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