Type II 11β-hydroxysteroid dehydrogenase expression in human colonic epithelial cells of inflammatory bowel disease

Ken Ichi Takahashi, Kouhei Fukushima, Hironobu Sasano, Iwao Sasaki, Seiki Matsuno, Zygmunt S. Krozowski, Hiroshi Nagura

研究成果: Article査読

21 被引用数 (Scopus)

抄録

Type II 11β-hydroxysteroid dehydrogenase endows specificity on the mineralocorticoid receptor by metabolizing cortisol and regulates sodium absorption in renal and colonic epithelium. Altered expression of this enzyme may be associated with impaired sodium absorption often seen in colonic mucosa of inflammatory bowel disease. The aim of this study was to investigate possible abnormality of 11β-hydroxysteroid dehydrogenase protein and mRNA expression in inflammatory bowel disease. In Crohn's disease, the colonic epithelium showed comparable levels of immunoreactivity and mRNA expression to those of control, except for the decreased immunoreactivity in severe inflamed lesions with deep ulcer. In contrary, a lack or decrease of immunoreactivity was relevant in ulcerative colitis regardless of the histological degree of inflammation. The mRNA expression was also significantly decreased in ulcerative colitis. This study demonstrates that abnormality of epithelial cells in ulcerative colitis includes the enzyme that regulates water and sodium absorption, which are physiologically essential.

本文言語English
ページ(範囲)2516-2522
ページ数7
ジャーナルDigestive Diseases and Sciences
44
12
DOI
出版ステータスPublished - 1999

ASJC Scopus subject areas

  • 生理学
  • 消化器病学

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