Adenocarcinoma of the larynx is a very rare neoplasm, accounting for 0.7% of all laryngeal malignant neoplasms. Laryngeal adenocarcinoma arises from minor salivary glands under the mucous membrane. We experienced two cases of laryngeal adenocarcinoma in the subglottic region. Herein, we report one case of laryngeal adenoid cystic carcinoma and another of adenocarcinoma, NOS. The first case was a 67-year-old man who was admitted to our hospital with the diagnosis of laryngeal adenoid cystic carcinoma in the subglottic region, which was stage T4aN0M0, for invasion of the cricoid cartilage. Partial laryngectomy was performed and the larynx was preserved. The other case was a 76-year-old female, who was admitted to our hospital with the diagnosis of laryngeal adenocarcinoma, NOS in the subglottic region. Tumor volume had already been reduced by resection with the laryngofissure approach by her previous doctor. She refused total laryngectomy and so received 70 Gy of irradiation therapy. There has been no evidence of recurrence for 16 months.
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