Two approaches to 14,15-secoergostane intermediates for the synthesis of strophasterols

Yuki Fukuda, Shuntaro Sato, Yusuke Ogura, Shigefumi Kuwahara

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Two protected 14,15-secoergostane derivatives suitable as pivotal intermediates for the synthesis of strophasterols A and B, anti-MRSA and neuronal cell-protecting natural products bearing a recently discovered strophastane skeleton, have been synthesized by two different routes. The first approach employed an oxidative cleavage of an α-hydroxy ketone intermediate with the Jones reagent as the key step to reach the targeted secoergostane from ergosterol in ten steps. In the second approach, an unprecedented reaction cascade composed of four reactions enabled us to obtain the secoergostane more efficiently in six steps.

本文言語English
ページ(範囲)986-992
ページ数7
ジャーナルBioscience, Biotechnology and Biochemistry
82
6
DOI
出版ステータスPublished - 2018

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

フィンガープリント

「Two approaches to 14,15-secoergostane intermediates for the synthesis of strophasterols」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル