Twenty-six new polymorphic microsatellite markers around the HLA-B, -C and -E loci in the human MHC class I region

G. Tamiya, M. Ota, Y. Katsuyama, T. Shiina, A. Oka, S. Makino, M. Kimura, H. Inoko

研究成果: Article査読

69 被引用数 (Scopus)

抄録

The human major histocompatibility complex (MHC) class I region is believed to contain a large number of disease-related loci for diseases such as Behçet's disease and psoriasis vulgaris. Although many novel genes have recently been identified in this region, it still appears to be difficult to relate any of these new genes to MHC class I-associated diseases as causative genetic factors. During the course of large-scale genomic sequencing of the human MHC class I region, we identified 262 microsatellite sequences with dinucleotide to pentanucleotide repeats around the HLA-B, -C and HLA-E genes. Of these, 26 microsatellites were investigated for repeat polymorphism using 60 HLA homozygous B-cell lines and 60 healthy random individuals. The average number of alleles at these microsatellite loci was 9.6 with a PIC (polymorphism content value) of 0.69. These new polymorphic microsatellite markers will probably be very useful for precise mapping of disease-related genes within the HLA class I region in linkage analysis. Moreover, they will provide a powerful tool to study recombination events in this region, which contributes to haplotypic diversification.

本文言語English
ページ(範囲)337-346
ページ数10
ジャーナルTissue Antigens
51
4 I
DOI
出版ステータスPublished - 1998 4
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 生化学
  • 遺伝学

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