TY - JOUR
T1 - Tumor uptake of [48V]Vanadyl-chlorine e6Na as a tumor-imaging agent in tumor-bearing mice
AU - Iwai, Kuni
AU - Kimura, Shuichi
AU - Ido, Tatsuo
AU - Iwata, Ren
PY - 1990
Y1 - 1990
N2 - [48V]Vanadyl-chlorine e6Na (48V-Chl) which was synthesized by insertion of 48V (positron emitter) into chlorine e6Na (Chl), a chlorophyll derivative having a similar structure to pheophorbide-a (Pheo), localized rapidly in experimental mammary carcinoma. The tumor-to-organ ratios of 48V-Chl were higher than those of 48V-labeled Pheo (48V-Pheo), and 48V-Chl showed a clear tumor image with low accumulation in liver, depending on the biodistribution of metal-free Chl having an affinity with tumor. 48V-Chl seems to be more suitable than 48V-Pheo as a tumor-imaging agent for photodynamic therapy of tumors.
AB - [48V]Vanadyl-chlorine e6Na (48V-Chl) which was synthesized by insertion of 48V (positron emitter) into chlorine e6Na (Chl), a chlorophyll derivative having a similar structure to pheophorbide-a (Pheo), localized rapidly in experimental mammary carcinoma. The tumor-to-organ ratios of 48V-Chl were higher than those of 48V-labeled Pheo (48V-Pheo), and 48V-Chl showed a clear tumor image with low accumulation in liver, depending on the biodistribution of metal-free Chl having an affinity with tumor. 48V-Chl seems to be more suitable than 48V-Pheo as a tumor-imaging agent for photodynamic therapy of tumors.
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U2 - 10.1016/0883-2897(90)90025-V
DO - 10.1016/0883-2897(90)90025-V
M3 - Article
C2 - 2079424
AN - SCOPUS:0025654280
VL - 17
SP - 775-777,779-780
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
SN - 0969-8051
IS - 8
ER -