Tumor suppressor functions of FBW7 in cancer development and progression

Zhiwei Wang; Hiroyuki Inuzuka; Jiateng Zhong; Lixin Wan; Hidefumi Fukushima; Fazlul H. Sarkar; Wenyi Wei

doi:10.1016/j.febslet.2012.03.017

Tumor suppressor functions of FBW7 in cancer development and progression

Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Lixin Wan, Hidefumi Fukushima, Fazlul H. Sarkar, Wenyi Wei

研究成果: Review article › 査読

134 被引用数 (Scopus)

抄録

FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its anti-tumor function primarily by promoting the degradation of various oncoproteins, through which FBW7 regulates cellular proliferation, differentiation and causes genetic instability. In this review, we will discuss the role of FBW7 downstream substrates and how dysregulation of Fbw7-mediated proteolysis of these substrates contributes to tumorigenesis. Additionally, we will also summarize the currently available various Fbw7-knockout mouse models that support Fbw7 as a tumor suppressor gene in the development and progression of human malignancies.

本文言語	English
ページ（範囲）	1409-1418
ページ数	10
ジャーナル	FEBS Letters
巻	586
号	10
DOI	https://doi.org/10.1016/j.febslet.2012.03.017
出版ステータス	Published - 2012 5月 21
外部発表	はい

ASJC Scopus subject areas

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1016/j.febslet.2012.03.017

他のファイルとリンク

引用スタイル

@article{03007d5b70c644dd9c08922903f5104f,

title = "Tumor suppressor functions of FBW7 in cancer development and progression",

abstract = "FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its anti-tumor function primarily by promoting the degradation of various oncoproteins, through which FBW7 regulates cellular proliferation, differentiation and causes genetic instability. In this review, we will discuss the role of FBW7 downstream substrates and how dysregulation of Fbw7-mediated proteolysis of these substrates contributes to tumorigenesis. Additionally, we will also summarize the currently available various Fbw7-knockout mouse models that support Fbw7 as a tumor suppressor gene in the development and progression of human malignancies.",

keywords = "Cancer, FBW7, Oncoprotein, SCF, Tumor suppressor, Ubiquitination",

author = "Zhiwei Wang and Hiroyuki Inuzuka and Jiateng Zhong and Lixin Wan and Hidefumi Fukushima and Sarkar, {Fazlul H.} and Wenyi Wei",

note = "Funding Information: We would like to sincerely apologize to all those colleagues whose important work has not been cited here due to space limitations. The authors{\textquoteright} work cited in this review was funded by grants from the National Institute of General Medicines, NIH (GM089763) to W.W., and Massachusetts Life Science Center New Investigator award (W.W.), and Department of Defense Prostate New Investigator award to W.W. is an American Cancer Society Scholar. Z.W. is supported by NIH NRSA fellowship.",

year = "2012",

month = may,

day = "21",

doi = "10.1016/j.febslet.2012.03.017",

language = "English",

volume = "586",

pages = "1409--1418",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "10",

}

TY - JOUR

T1 - Tumor suppressor functions of FBW7 in cancer development and progression

AU - Wang, Zhiwei

AU - Inuzuka, Hiroyuki

AU - Zhong, Jiateng

AU - Wan, Lixin

AU - Fukushima, Hidefumi

AU - Sarkar, Fazlul H.

AU - Wei, Wenyi

N1 - Funding Information: We would like to sincerely apologize to all those colleagues whose important work has not been cited here due to space limitations. The authors’ work cited in this review was funded by grants from the National Institute of General Medicines, NIH (GM089763) to W.W., and Massachusetts Life Science Center New Investigator award (W.W.), and Department of Defense Prostate New Investigator award to W.W. is an American Cancer Society Scholar. Z.W. is supported by NIH NRSA fellowship.

PY - 2012/5/21

Y1 - 2012/5/21

N2 - FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its anti-tumor function primarily by promoting the degradation of various oncoproteins, through which FBW7 regulates cellular proliferation, differentiation and causes genetic instability. In this review, we will discuss the role of FBW7 downstream substrates and how dysregulation of Fbw7-mediated proteolysis of these substrates contributes to tumorigenesis. Additionally, we will also summarize the currently available various Fbw7-knockout mouse models that support Fbw7 as a tumor suppressor gene in the development and progression of human malignancies.

AB - FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its anti-tumor function primarily by promoting the degradation of various oncoproteins, through which FBW7 regulates cellular proliferation, differentiation and causes genetic instability. In this review, we will discuss the role of FBW7 downstream substrates and how dysregulation of Fbw7-mediated proteolysis of these substrates contributes to tumorigenesis. Additionally, we will also summarize the currently available various Fbw7-knockout mouse models that support Fbw7 as a tumor suppressor gene in the development and progression of human malignancies.

KW - Cancer

KW - FBW7

KW - Oncoprotein

KW - SCF

KW - Tumor suppressor

KW - Ubiquitination

UR - http://www.scopus.com/inward/record.url?scp=84861189396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861189396&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2012.03.017

DO - 10.1016/j.febslet.2012.03.017

M3 - Review article

C2 - 22673505

AN - SCOPUS:84861189396

VL - 586

SP - 1409

EP - 1418

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 10

ER -

Tumor suppressor functions of FBW7 in cancer development and progression

抄録

ASJC Scopus subject areas

UN SDG

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル