TRP channels: Molecular diversity and physiological function

Motohiro Nishida, Yuji Hara, Takashi Yoshida, Ryuji Inoue, Yasuo Mori

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Calcium ions (Ca2+) are particularly important in cellular homeostasis and activity. To elicit physiologically relevant timing and spatial patterns of Ca2+ signaling, ion channels in the surface of each cell precisely control Ca2+ influx across the plasma membrane. A group of surface membrane ion channels called receptor-activated cation/Ca2+ channels (RACCs) are activated by diverse cellular stimuli from the surrounding extracellular environment via receptors and other pathways such as heat, osmotic pressure, and mechanical and oxidative stress. An important clue to understanding the molecular mechanisms underlying the functional diversity of RACCs was first attained by molecular identification of the transient receptor potential (trp) protein (TRP), which mediates light-induced depolarization in Drosophila photoreceptor cells, and its homologues from various biological species. Recent studies have revealed that respective TRP channels are indeed activated by characteristic cellular stimuli. Furthermore, the involvement of TRP channels has been demonstrated in the signaling pathways essential for tissue-specific functions as well as ubiquitous biological responses, such as cell proliferation, differentiation, and death. These findings encourage the usage of TRP channels and their signalplexes as powerful tools for developing novel pharmaceutical targets.

本文言語English
ページ(範囲)535-550
ページ数16
ジャーナルMicrocirculation
13
7
DOI
出版ステータスPublished - 2006 10 1
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 分子生物学
  • 循環器および心血管医学
  • 生理学(医学)

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