Tropone skeleton enhances the dispersion stability of nano-prodrugs

Keita Tanita, Yoshitaka Koseki, Takaaki Kamishima, Hitoshi Kasai

    研究成果: Article査読

    2 被引用数 (Scopus)

    抄録

    We synthesized hinokitiol-modified SN-38 prodrugs and fabricated their nano-prodrugs which are nanoparticles composed of only prodrug molecules by the reprecipitation method. These nano-prodrugs possessed high dispersion stability, and further research revealed that the tropone skeleton of hinokitiol is the key structure for the dispersion stability in our prodrug design. In addition, the nanoparticles of hinokitiol-modified SN-38 showed much higher cytotoxicity against cancer cells than irinotecan, the pharmaceutically available prodrug of SN-38.

    本文言語English
    ページ(範囲)222-224
    ページ数3
    ジャーナルChemistry Letters
    49
    3
    DOI
    出版ステータスPublished - 2020

    ASJC Scopus subject areas

    • 化学 (全般)

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