Trends of genetic relationship of serotype 23F penicillin-resistant streptococcus pneumoniae in Japan

Ryoji Yoshida, Yoichi Hirakata, Mitsuo Kaku, Hiromu Takemura, Hironori Tanaka, Kazunori Tomono, Hironobu Koga, Shigeru Kohno, Shimeru Kamihira

研究成果: Article査読

8 被引用数 (Scopus)

抄録

No data on the genetic analysis of penicillin-resistant Streptococcus pneumoniae (PRP) in Japan has been reported. The Smal restriction endonuclease digested patterns of chromosomal DNAs from 15 PRP serotyped 23F isolated in Japan were analyzed by pulsed-field gel electrophoresis (PFGE). The isolates were genetically heterogeneous and seven different PFGE patterns were identified. Nine strains were also resistant to erythromycin and tetracycline. Four strains revealed resistance to ceftriaxone. The PFGE patterns of some strains isolated in Nagasaki University Hospital were identical to each other and closely resembled those of isolates from three different areas of Japan. These results indicate a need for additional studies by PFGE to determine the possibility of clonal spread in Japan.

本文言語English
ページ(範囲)232-238
ページ数7
ジャーナルChemotherapy
43
4
DOI
出版ステータスPublished - 1997 1 1
外部発表はい

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

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