Tremorgenic indole alkaloids. Studies directed toward the assembly of the A, F, and I rings of penitrem D: Observation of an unexpected stereochemical outcome

Amos B. Smith, Naoki Kanoh, Noriaki Minakawa, Jon D. Rainier, Frances R. Blase, Richard A. Hartz

研究成果: Article査読

26 被引用数 (Scopus)

抄録

(matrix presented) In this Letter we demonstrate the viability of a highly stereoselective tandem Mannich cyclization-grammine fragmentation/addition cascade, critical for assembly of the A and F rings of penitrem D. We also explored simultaneous execution of this tactic with concurrent construction of ring I. Reinvestigation of a model system provided an explanation for the unanticipated stereochemical outcome at C(28).

本文言語English
ページ(範囲)1263-1266
ページ数4
ジャーナルOrganic letters
1
8
DOI
出版ステータスPublished - 1999 10月 21
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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