Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter

S. N. Laxmi, S. Takahashi, K. Matsumoto, S. Higano, N. Kurihara, M. Imaizumi, K. Abe, Y. Itoyama, K. Sakamoto

研究成果: Article査読

16 被引用数 (Scopus)

抄録

This report describes unique contrast enhancement of the white matter on T1-weighted magnetic resonance images of two patients with disseminated necrotizing leukoencephalopathy, which developed acute lymphoblastic leukemia treated with high-dose methotrexate. In both patients, the enhancement was more pronounced near the base of the brain than at the vertex. Necropsy of the first case revealed loss of myelination and necrosis of the white matter. Possible mechanisms causing such a leukoencephalopathy are discussed.

本文言語English
ページ(範囲)303-307
ページ数5
ジャーナルRadiation Medicine - Medical Imaging and Radiation Oncology
14
6
出版ステータスPublished - 1996 12 1

ASJC Scopus subject areas

  • 放射線
  • 放射線学、核医学およびイメージング
  • 腫瘍学

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