TY - JOUR
T1 - Treatment of covid-19-related olfactory disorder promoted by kakkontokasenkyushin’i
T2 - A case series
AU - Takayama, Shin
AU - Arita, Ryutaro
AU - Ono, Rie
AU - Saito, Natsumi
AU - Suzuki, Satoko
AU - Kikuchi, Akiko
AU - Ohsawa, Minoru
AU - Tadano, Yasunori
AU - Akaishi, Tetsuya
AU - Tanaka, Junichi
AU - Kanno, Takeshi
AU - Abe, Michiaki
AU - Onodera, Ko
AU - Ishii, Tadashi
N1 - Funding Information:
We thank Akiko Kuwabara, a Clinical Research Coordinator. We would also like to thank Editage (https:// www.editage.com) for English language editing. This study was supported by a research grant from TSUMURA and Co., Tokyo, Japan.S.T., A.K., M.O. and T.I. belong to the Department of Kampo and Integrative Medicine at Tohoku University School of Medicine. The department received a grant from Tsumura, a Japanese manufacturer of Kampo medicine; however, the grant was used as per Tohoku University rules. Potential conflicts of interests were addressed by the Tohoku University Benefit Reciprocity Committee and were managed appropriately.
Funding Information:
We thank Akiko Kuwabara, a Clinical Research Coordinator. We would also like to thank Editage (https:// www.editage.com) for English language editing. This study was supported by a research grant from TSUMURA and Co., Tokyo, Japan.
Publisher Copyright:
© 2021 Tohoku University Medical Press.
PY - 2021
Y1 - 2021
N2 - Olfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin’i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory disorder presented with a blocked nose, nasal discharge or taste impairment. Physical examination using Kampo medicine showed similar findings, such as a red tongue with red spots and sublingual vein congestion, which presented as blood stasis and inflammation; thus, we prescribed the Kampo medicine, kakkontokasenkyushin’i. After administration, the numeric rating scale scores of the smell impairment improved within 3 days from 9 to 3 in case 1, from 10 to 0 in case 2, from 9 to 0 in case 3, from 5 to 0 in case 4, and from 9 to 0 within 5 days in case 5. Following the treatment, other common cold symptoms were also alleviated. Kakkontokasenkyushin’i can be used for treating nasal congestion, rhinitis, and inflammation in the nasal mucosa. The olfactory disorder in COVID-19 has been reportedly associated with inflammation and congestion, especially in the olfactory bulb and olfactory cleft. Kakkontokasenkyushin’i may be one of the treatment alternatives for the olfactory disorder with rhinitis in patients with COVID-19.
AB - Olfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin’i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory disorder presented with a blocked nose, nasal discharge or taste impairment. Physical examination using Kampo medicine showed similar findings, such as a red tongue with red spots and sublingual vein congestion, which presented as blood stasis and inflammation; thus, we prescribed the Kampo medicine, kakkontokasenkyushin’i. After administration, the numeric rating scale scores of the smell impairment improved within 3 days from 9 to 3 in case 1, from 10 to 0 in case 2, from 9 to 0 in case 3, from 5 to 0 in case 4, and from 9 to 0 within 5 days in case 5. Following the treatment, other common cold symptoms were also alleviated. Kakkontokasenkyushin’i can be used for treating nasal congestion, rhinitis, and inflammation in the nasal mucosa. The olfactory disorder in COVID-19 has been reportedly associated with inflammation and congestion, especially in the olfactory bulb and olfactory cleft. Kakkontokasenkyushin’i may be one of the treatment alternatives for the olfactory disorder with rhinitis in patients with COVID-19.
KW - Blocked nose
KW - Coronavirus disease
KW - Kakkontokasenkyushin’i
KW - Kampo medicine
KW - Olfactory disorder Tohoku J. Exp. Med., 2021 June, 254 (2), 71-80
UR - http://www.scopus.com/inward/record.url?scp=85108008557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108008557&partnerID=8YFLogxK
U2 - 10.1620/tjem.254.71
DO - 10.1620/tjem.254.71
M3 - Article
C2 - 34108344
AN - SCOPUS:85108008557
VL - 254
SP - 71
EP - 80
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 2
ER -