Treadmill exercise prevents reduction of bone mineral density after myocardial infarction in apolipoprotein E-deficient mice

Masanori Kanazawa, Yasuharu Matsumoto, Kikuyo Takahashi, Hideaki Suzuki, Hironori Uzuka, Kensuke Nishimiya, Hiroaki Shimokawa

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Aims: Recent clinical studies demonstrated the association between myocardial infarction (MI) and osteoporotic fractures. We examined whether MI causes bone loss and the effects of exercise training on bone in mice after MI. Methods: We created a MI model in 16-week-old male apolipoprotein E-deficient mice (n = 42), which were randomly assigned to exercise group (MI-Ex) and sedentary group (MI-Sed). We also performed sham operations in other mice (n = 10). Treadmill exercise training was performed from one week after operation to eight weeks. At eight weeks, the bone parameters of the femur were measured by quantitative computed tomography, followed by histological analysis (n = 10–17). Results: Bone mineral density (BMD) of the femur was significantly decreased in the MI-Sed group as compared with the sham group (P < 0.001), whereas the BMD was significantly increased in the MI-Ex group as compared with the MI-Sed group (P < 0.05). In histological analysis, Rho-associated coiled-coil kinase 2 and tartrate-resistant acid phosphate positive (bone resorptive) area in distal femur were significantly increased in the MI-Sed group as compared with the sham group (P < 0.05), whereas those parameters were significantly decreased in the MI-Ex group as compared with the MI-Sed group (P < 0.05). In contrast, alkaline phosphatase (ALP)-positive (bone-forming) area was significantly decreased in the MI-Sed group as compared with the sham group (P < 0.05), whereas ALP-positive area was significantly increased in the MI-Ex group as compared with the MI-Sed group (P < 0.05). Conclusions: The present study demonstrates that MI reduces BMD and treadmill exercise training prevents the reduction of BMD in apolipoprotein E-deficient mice.

本文言語English
ページ(範囲)28-35
ページ数8
ジャーナルEuropean Journal of Preventive Cardiology
27
1
DOI
出版ステータスPublished - 2020 1 1

ASJC Scopus subject areas

  • 疫学
  • 循環器および心血管医学

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