Transplantation of preserved pancreatic islets into the portal vein of rats

Gunji Yamazaki, Gizo Nakagawara, Hiroshi Okamoto, Ryuichi Akimoto, Shoichi Kimura, Yasuhiko Kojima, Itsuo Miyazaki

研究成果: Article査読

抄録

Langerhans islets were isolated from the exocrine pancreata of Wistar rats by the improved collagenase-digestion method. The isolated islets were preserved in a tissue culture medium for seven days. Transplantation of these preserved islets into the portal vein of streptozotocin-induced diabetic rats resulted in a significant reduction of hyperglycemia, polyuria and glucosuria, and a restoration of weight gain. It was found that these effects could be maintained for 16 weeks. In order to normalize the K-values and plasma insulin levels, at least 600 islets had to be transplanted into each diabetic rat.

本文言語English
ページ(範囲)152-158
ページ数7
ジャーナルThe Japanese Journal of Surgery
8
2
DOI
出版ステータスPublished - 1978 6 1
外部発表はい

ASJC Scopus subject areas

  • Surgery

フィンガープリント 「Transplantation of preserved pancreatic islets into the portal vein of rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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