Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord

Takahito Kamada, Masao Koda, Mari Dezawa, Katsunori Yoshinaga, Masayuki Hashimoto, Shuhei Koshizuka, Yutaka Nishio, Hideshige Moriya, Masashi Yamazaki

研究成果: Article査読

128 被引用数 (Scopus)

抄録

The aim of this study was to evaluate whether transplantation of Schwann cells derived from bone marrow stromal cells (BMSC-SCs) promotes axonal regeneration and functional recovery in completely transected spinal cord in adult rats. Bone marrow stromal cells (BMSCs) were induced to differentiate into Schwann cells in vitro. A 4-mm segment of rat spinal cord was removed completely at the T7 level. An ultra-filtration membrane tube, filled with a mixture of Matrigel (MG) and BMSC-SCs (BMSC-SC group) or Matrigel alone (MG group), was grafted into the gap. In the BMSC-SC group, the number of neurofilament- and tyrosine hydroxylase-immunoreactive nerve fibers was significantly higher compared to the MG group, although 5-hydroxytryptamine- or calcitonin gene-related peptide-immunoreactive fibers were rarely detectable in both groups. In the BMSC-SC group, significant recovery of the hindlimb function was recognized, which was abolished by retransection of the graft 6 weeks after transplantation. These results demonstrate that transplantation of BMSC-SCs promotes axonal regeneration of lesioned spinal cord, resulting in recovery of hindlimb function in rats. Transplantation of BMSC-SCs is a potentially useful treatment for spinal cord injury.

本文言語English
ページ(範囲)37-45
ページ数9
ジャーナルJournal of Neuropathology and Experimental Neurology
64
1
DOI
出版ステータスPublished - 2005 1月
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 神経学
  • 臨床神経学
  • 細胞および分子神経科学

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