Transition-metal-catalyzed selective cyclization strategy to 2-substituted benzofurans and indoles en route to the oxa analogues of isocryptolepine

Satrajit Indu, Parthasarathi Subramanian, Krishna P. Kaliappan

研究成果: Article査読

15 被引用数 (Scopus)

抄録

A selective catalytic route to benzofurans and indoles from similar starting materials has been developed. A two-step protocol that involves a transition-metal-catalyzed domino Sonogashira coupling between 2-ethynylanilines and 2-iodophenols followed by selective O- and N-cyclizations afforded 2-(benzofuran-2-yl)anilines and 2-(indol-2-yl)phenols, respectively. The 2-(benzofuran-2-yl)anilines were further utilized in a Lewis acid catalyzed Pictet-Spengler-type cyclization to prepare the oxa analogues of isocryptolepine.

本文言語English
ページ(範囲)7193-7202
ページ数10
ジャーナルEuropean Journal of Organic Chemistry
2014
32
DOI
出版ステータスPublished - 2014 11
外部発表はい

ASJC Scopus subject areas

  • 物理化学および理論化学
  • 有機化学

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