Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor

Kentaro Abe, Sumiko Matsui, Dai Watanabe

研究成果: Article

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Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic activity of cAMP response element-binding protein (CREB) transcription factor. By viral vector-mediated modification of genomic DNA, we established germ line-transmitted lines of zebra finches, which exhibited enhanced or suppressed activity of CREB. Although intrinsically acquired vocalizations or their hearing ability were not affected, the transgenic birds showed reduced vocal learning quality of their own songs and impaired audio-memory formation against conspecific songs. These results thus demonstrate that appropriate activity of CREB is necessary for the postnatal acquisition of learned behavior in songbirds, and the CREB transgenic birds offer a unique opportunity to separately manipulate both genetic and environmental factors that impinge on the postnatal song learning.

元の言語English
ページ(範囲)7599-7604
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
112
発行部数24
DOI
出版物ステータスPublished - 2015 6 16
外部発表Yes

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