Transgenic rice expressing amyloid β-peptide for oral immunization

Taiji Yoshida, Eiichi Kimura, Setsuo Koike, Jun Nojima, Eugene Futai, Noboru Sasagawa, Yuichiro Watanabe, Shoichi Ishiura

研究成果: Article査読

22 被引用数 (Scopus)

抄録

Various vaccine therapies for Alzheimer's disease (AD) have been investigated. Here we report transgenic rice expressing amyloid β-peptide (Aβ). The Aβ42 gene fused with a green fluorescent protein gene was introduced into rice using the Agrobacterium method. When transgenic brown rice expressing Aβ was orally administered to mice, serum anti-Aβ antibody titers were elevated. The same results were observed when mice were fed boiled, transgenic brown rice. The results indicate that an edible vaccine against AD using rice may be feasible. A vaccine derived from rice would be far cheaper than existing medical vaccines.

本文言語English
ページ(範囲)301-307
ページ数7
ジャーナルInternational Journal of Biological Sciences
7
3
DOI
出版ステータスPublished - 2011
外部発表はい

ASJC Scopus subject areas

  • 生態、進化、行動および分類学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 発生生物学
  • 細胞生物学

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