Transgenic copper/zinc-superoxide dismutase ameliorates caerulein-induced pancreatitis in mice

Yoshifumi Kikuchi, Tooru Shimosegawa, Shigeki Moriizumi, Kenji Kimura, Akihiko Satoh, Masaru Koizumi, Ichiro Kato, Charles J. Epstein, Takayoshi Toyota

研究成果: Article査読

17 被引用数 (Scopus)

抄録

The role of oxidative stress in acute pancreatitis was investigated by comparing the pathological features of caerulein pancreatitis between transgenic mice that overexpress human Cu/Zn-superoxide dismutase (SOD) and nontransgenic littermates. Both the elevation of serum amylase and the formation of pancreatic edema during the pancreatitis were significantly reduced in the transgenic mice compared with the nontransgenic littermates. In the transgenic mice, the pancreatitis-associated reduction of Cu/Zn-SOD activity in the pancreatic tissues was significantly smaller than that in the nontransgenic mice. These results provide direct evidence that the elevation of intracellular oxygen radicals is an important factor for the progress of acute edematous pancreatitis.

本文言語English
ページ(範囲)177-181
ページ数5
ジャーナルBiochemical and biophysical research communications
233
1
DOI
出版ステータスPublished - 1997 4 7
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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