Transcriptional and epigenetic control of brown and beige adipose cell fate and function

Takeshi Inagaki, Juro Sakai, Shingo Kajimura

研究成果: Review article査読

125 被引用数 (Scopus)

抄録

White adipocytes store excess energy in the form of triglycerides, whereas brown and beige adipocytes dissipate energy in the form of heat. This thermogenic function relies on the activation of brown and beige adipocyte-specific gene programmes that are coordinately regulated by adipose-selective chromatin architectures and by a set of unique transcriptional and epigenetic regulators. A number of transcriptional and epigenetic regulators are also required for promoting beige adipocyte biogenesis in response to various environmental stimuli. A better understanding of the molecular mechanisms governing the generation and function of brown and beige adipocytes is necessary to allow us to control adipose cell fate and stimulate thermogenesis. This may provide a therapeutic approach for the treatment of obesity and obesity-associated diseases, such as type 2 diabetes.

本文言語English
ページ(範囲)480-495
ページ数16
ジャーナルNature Reviews Molecular Cell Biology
17
8
DOI
出版ステータスPublished - 2016 7 21
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

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