Transcriptional activity of nuclei from WI‐38 cells at various passages

Kiyoshi Nose, Hiroshi Okamoto

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Transcriptional activity of nuclei from human diploid fibroblast (WI‐38) cells at different passage levels was studied with endogenous RNA polymerase. The rate and extent of the RNA synthesis decreased when the nuclei were were prepared from senescent cells. The decreased activity of RNA synthesis in senescent cell nuclei was demonstrated from both the transcriptional assay and the estimation of the processing activity, i.e., polyadenylation of the transcripts.

本文言語English
ページ(範囲)51-54
ページ数4
ジャーナルJournal of Cellular Physiology
102
1
DOI
出版ステータスPublished - 1980 1
外部発表はい

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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